Two integrated analyses reporting this outcome found significant reductions in interpersonal difficulty related to ejaculation compared with placebo at study endpoint, ie, McMahon et al integrated results from five studies and Porst et al integrated results from two studies. The objective of this article is to review evidence supporting the efficacy and safety of dapoxetine in the treatment of PE. Interpersonal difficulty related to ejaculation Changes from baseline in interpersonal difficulty related to ejaculation following dapoxetine therapy were reported in five studies Table 3. It can also increase the risk of fainting. Patient-reported outcome-defined level of clinical benefit Three of the RCTs in Table 3 also reported a predefined composite clinical outcome as a measure of clinical benefit following dapoxetine treatment. · Dapoxetine oral. Updated 2 Feb | Selective serotonin re-uptake inhibitors Premature ejaculation. Share. Check interactions. Drugs List. Therapeutic Indications. Dosage. Contraindications. Precautions and Warnings. Dapoxetine is a short-acting SSRI drug currently being considered for approval by the Food and Drug Administration (FDA) for the treatment of premature ejaculation in men, which would make it the first drug approved for such treatment. Report an error. Dapoxetine is a medicine used for the treatment of premature ejaculation (a sexual dysfunction in which a man ejaculates too quickly during sexual intercourse). This medicine helps in increasing the time taken to ejaculate and achieving better control over ejaculation during sexual intercourse.